HORDB

General Information

ID: hor003220
Uniprot ID: NA
Protein name: Leu-enkephalin
Gene name: NA
Organism: NA
Family: Opioid neuropeptide precursor family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: NA
GO MF: NA
GO BP: NA
GO CC: NA

Sequence Information

Sequence: YGFL
Length: 4
Propeptide: NA
Signal peptide: NA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Activity

Function: NA
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure

Disulfide bond: NA
Structure ID: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor003220_AF2.pdb

hor003220_ESM.pdb

Physical Information

Mass:	55227	Formula:	C26H34N4O6
Absent amino acids:	ACDEHIKMNPQRSTVW	Common amino acids:	FGLY
pI:	6.09	Basic residues:	0
Polar residues:	2	Hydrophobic residues:	2
Hydrophobicity:	122.5	Boman Index:	870
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	97.5
Instability Index:	-1372.5	Extinction Coefficient cystines:	1490
Absorbance 280nm:	496.67

Literature

PubMed ID: 1540207
Title: Reciprocal Effects Between opioid neuropeptide precursor family Peptides and Human Polymorphonuclear leukocytes--I. Chemical Modifications of Leu-enkephalin by Phorbol Myristate Acetate-Stimulated Polymorphonuclear Leukocytes