General Information

  • ID:  hor003220
  • Uniprot ID:  NA
  • Protein name:  Leu-enkephalin
  • Gene name:  NA
  • Organism:  NA
  • Family:  Opioid neuropeptide precursor family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  YGFL
  • Length:  4
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003220_AF2.pdbhor003220_ESM.pdb

Physical Information

Mass: 55227 Formula: C26H34N4O6
Absent amino acids: ACDEHIKMNPQRSTVW Common amino acids: FGLY
pI: 6.09 Basic residues: 0
Polar residues: 2 Hydrophobic residues: 2
Hydrophobicity: 122.5 Boman Index: 870
Half-Life / Aliphatic Index: 2.8 hour Aliphatic Index: 97.5
Instability Index: -1372.5 Extinction Coefficient cystines: 1490
Absorbance 280nm: 496.67

Literature

  • PubMed ID:  1540207
  • Title:  Reciprocal Effects Between opioid neuropeptide precursor family Peptides and Human Polymorphonuclear leukocytes--I. Chemical Modifications of Leu-enkephalin by Phorbol Myristate Acetate-Stimulated Polymorphonuclear Leukocytes